I did not expect that I'd quote the Catholic Church on this blog.
But they do a good job at expressing the problems with Transhumanism.

From the [Encyclical Letter Magnifica Humanitas](https://www.vatican.va/content/leo-xiv/en/encyclicals/documents/20260515-magnifica-humanitas.html#Underlying_narratives:_)
(emphasis mine):

> ## Underlying narratives: transhumanism and posthumanism
>
> 115. In an attempt to shed light on the cultural assumptions accompanying the ongoing digital revolution, I would now like to turn our attention to certain currents of thought that interpret progress as surpassing the human condition, and which are often grouped under the labels of transhumanism and posthumanism. These perspectives form the ideological background present in some centers of technological power and occupy the collective imagination in a simplified form, especially in the media and on social networks. They tend to foster enthusiasm for new technologies through a futuristic vision of an “enhanced human being” or “human-machine hybrid.”
>
> 116. Transhumanism and posthumanism encompass a range of currents and sensibilities, making it difficult to define them in a single, unambiguous way. They can be likened to an archipelago of conceptual “islands,” distinct yet connected by a common “sea” of assumptions, namely the central role of technology and the aspiration to transcend the limits of the human condition. In general, transhumanism envisions the enhancement of human beings through technologies — such as biomedicine, body engineering, devices and algorithms — with the aim of increasing performance and capabilities. Posthumanism, especially in its more radical forms, goes further: it challenges anthropocentrism and envisions a hybridization of human beings, machines and the environment, even anticipating a threshold where humanity surpasses itself in a new evolutionary stage. Even when such ideas remain largely speculative, they gain relevance by altering the collective imagination and thereby influence social, economic and political choices. [129]
>
> 117. From the perspective of the Church’s Social Doctrine, **the key issue is not the use of technology as such, but the vision that underlies it. If the human being is treated as something to be perfected or surpassed, it becomes easier to accept that some lives are less useful, less desirable or less worthy. In the name of progress, “necessary sacrifices” may begin to be justified, placing the burden on the most vulnerable in pursuit of a supposed optimization of the species.** In this regard, the aforementioned warning of Saint Paul VI retains great foresight: indeed, scientific and technological advances, when detached from moral and social progress, end up turning against humanity. [130] For this reason, a clear distinction must be made. It is one thing to integrate technology within a human-centered, relational vision; it is quite another to be guided by an outlook that devalues human limits and promises a purely technical form of “salvation.”

Transhumanism is not an acceptable vision of the future,
and the Catholic Church is right to point it out.